1. 发育与衰老研究团队
发育与衰老研究团队现有成员20余人，其中高级职称4人、中级职称5人，在读研究生10余人。团队汇聚了包括“中国科协青年人才托举工程”入选者、四川省学术和技术带头人及其后备人选在内的多层次人才，形成了学缘结构合理、专业优势互补、研究方向集中的科研梯队。近年来，团队骨干成员参与国家科技创新2030-脑科学重大项目1项，并牵头建设了中国人脑组织库协作联盟-304永利集团登录入口人脑组织库。团队先后主持国家自然科学基金、省部级科研项目等各类课题20余项；在国内外高水平期刊上发表学术论文近30篇，出版著作5部。多次在重要国际、国内学术会议上进行报告，累计近10余次。研究方向：（1）发育与衰老的共性机制；（2）衰老与神经退行性疾病。
部分代表性论文如下：
作者 |
题目 |
苏炳银 |
Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice |
苏炳银 |
Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling |
苏炳银 |
Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson’s disease |
苏炳银 |
Mcm5 Represses Endodermal Migration through Cxcr4a-itgb1b Cascade Instead of Cell Cycle Control |
太颢然 |
Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation |
太颢然 |
SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect |
太颢然 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 |
韩玉萍 |
Curcumin inhibits propofol-induced autophagy of MN9D cells via Akt/mTOR/p70S6K signaling pathway |
韩玉萍 |
Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms |
谭泓琳 |
Lipid metabolism characterization in gastric cancer identifies signatures to predict prognostic and therapeutic responses |
2. 基因哨兵与微免平衡团队
基因哨兵与微免平衡团队成立于2012年，现有30余人，包括高级职称9人，中级职称9人，研究生10余人，围绕学校老年医学学科特色发展，以微生物感染为研究方向，聚焦非编码RNA与微生物生理生化关系，开拓RNA等生物药物在临床方面的应用。团队承担国家级科研项目30余项，参与国家重点研发计划1项，省部级项目30余项，总金额3000余万元。近5年团队发表学术论文100余篇，代表作包括Cell、Science及CNS子刊，如Nature Communications、CellMetabolism等；团队发表新冠病毒研究相关SCI论文60余篇，申请国家专利20余项。
研究方向：1.细菌耐药与应对策略2.功能益生菌与老年健康3.非编码RNA与药物
部分代表性论文如下：
作者 |
题目 |
贾旭、刘兴梅 |
Small molecule inhibitor targets OmpV to treat pandemic Vibrio cholerae infection |
贾旭 |
Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens |
贾旭 |
Screening of Novel Inhibitors Targeting the Non-ATP-binding Domain of Staphylococcus aureus SecA1 |
贾旭 |
Functional Characterization and Protein Engineering of Salvia miltiorrhiza Rosmarinic Acid Synthase |
贾旭 |
Adsorption behavior and mechanism of salvianolic acid A on surface molecularly imprinted nonwoven fabrics |
贾旭 |
Antibody-drug conjugates: A new twist to overcome EGFR-TKIs resistance in non-small cell lung cancer |
贾旭 |
Lactic acid bacteria with a strong antioxidant function isolated from "Jiangshui," pickles, and feces, Frontiers in Microbiology |
贾旭 |
Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies |
贾旭、杜婷 |
A promising nucleic acid therapy drug: DNAzymes and its delivery system |
贾旭 |
The development and application of pseudoviruses: assessment of SARS-CoV-2 pseudoviruses |
贾旭 |
The function of small RNA in Pseudomonas aeruginosa |
贾旭 |
Trends and implications of antimicrobial resistance in Pseudomonas aeruginosa: Insights from a 19-year study in Zhejiang Province |
贾旭 |
Effects of Traditional Chinese Medicine and its Active Ingredients on Drug-Resistant Bacteria |
贾旭 |
Engineered probiotics |
贾旭 |
Promising natural products against SARS‐CoV‐2:Structure, function, and clinical trials |
3. 稳态调控与跨系统老年疾病团队
稳态调控与跨系统老年疾病团队拥有教师8人，含博士7人。近5年来，共获批科研项目15项，经费298万元，含国家自然科学基金3项。主要的研究方向有炎症性发热的神经机制，退热与调节性低温反应的神经机制，能量代谢性异常疾病的神经机制。
部分代表性论文如下：
作者 |
题目 |
唐 瑜 |
Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4 |
胥建辉 |
Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice. |
张 洁 |
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats |
张 洁 |
The role of prostaglandin E2 synthesized in rat lateral parabrachial nucleus in LPS-induced fever |
张 洁 |
Imidazoline 1 receptors mediate the hyperthermia induced by preoptic agmatine application in male rats |
唐 瑜 |
Arginine vasopressin antagonizes the effects of prostaglandin E2 on the spontaneous activity of warm-sensitive and temperature-insensitive neurons in |
胥建辉 |
The hyperthermic response to intra-preoptic area administration of agmatine in male rats |
胥建辉 |
Arginine vasopressin differentially modulates GABAergic synaptic transmission onto temperature-sensitive and temperature-insensitive neurons in the rat preoptic area |
张 洁 |
Electrophysiological properties of thermosensitive neurons in slices of rat lateral parabrachial nucleus |
4. 器官发育稳态与疾病团队
器官发育稳态与疾病团队拥有教师22人，含博士7人。近5年来，共获批科研项目近40项，经费近400万元，含国家自然科学基金3项，省部级项目7项。主要的研究方向包括肝脏发育与再生、脂肪肝与肝癌等肝病发病机制与干预等方向。
部分代表性论文如下：
作者 |
题目 |
黄四洲 |
Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. |
黄四洲 |
Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms. |
黄四洲 |
RNA-seq identifies Amd1 as a regulator of hepatocyte proliferation via Skp2 during liver development and hepatocellular carcinoma progression in zebrafish. |
王黎燕 |
miR24-2 promotes malignant progression of human liver cancer stem cells by enhancing tyrosine kinase Src epigenetically |
王黎燕 |
miR-933 accelerates the growth of liver cancer cells by enhancing pyruvate kinase isoform M2 |
王黎燕 |
CircHULC accelerates the growth of human liver cancer stem cells by enhancing chromatin reprogramming and chromosomal instability via autophagy |
欧阳舒毓 |
Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression |
欧阳舒毓 |
Development of 3D-QSAR models for predicting the activities of chemicals to stimulate muscle growth via β2-adrenoceptor |
欧阳舒毓 |
Current Advances in Immunoassays for the Detection of β2-Agonists |
马棁铫 |
Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction |
马棁铫 |
Ribonuclease Inhibitor 1 (RNH1) Regulates Sperm tsRNA Generation for Paternal Inheritance through Interacting with Angiogenin in the Caput Epididymis |
